Microglia: origins, homeostasis, and roles in myelin repair
نویسندگان
چکیده
منابع مشابه
Roles of microglia in brain development, tissue maintenance and repair.
The emerging roles of microglia are currently being investigated in the healthy and diseased brain with a growing interest in their diverse functions. In recent years, it has been demonstrated that microglia are not only immunocentric, but also neurobiological and can impact neural development and the maintenance of neuronal cell function in both healthy and pathological contexts. In the diseas...
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Microglia is a type of glial cell located throughout the central nervous system (CNS), which is sensitive to CNS injury and disease. Responsibility of microglia as the resident macrophage cells for injuries suggests that these cells have the potential to act as diagnostic markers of disease beginning or progression. Function of Microglia is strongly synchronized by the microenvironment of brain...
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We used a bone marrow transplantation approach to distinguish the activities of bone marrow-derived macrophages from the activities of central nervous system-resident microglia in phenomena associated with axon demyelination and remyelination. We transplanted wild type or germline NG2 null beta-actin-EGFP expressing bone marrow into irradiated wild type or NG2 null recipient mice, followed by a...
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The blood clotting protein fibrinogen can inadvertently promote multiple sclerosis (MS) when it leaks from the blood into the brain. According to Adams et al. (page 571), it does so by activating microglia and sending these cells into phagocytic overdrive. Interrupting this interaction may yield a treatment for MS that doesn’t interfere with blood clotting. The neurological dysfunction seen in ...
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[This corrects the article DOI: 10.3389/fcell.2016.00071.].
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ژورنال
عنوان ژورنال: Current Opinion in Neurobiology
سال: 2017
ISSN: 0959-4388
DOI: 10.1016/j.conb.2017.10.001